Differences in rate of change of retinal structural and microvasculature parameters in parkinson’s disease compared to controls

Background Prior cross-sectional studies have revealed decreased macular perfusion density (PFD) and increased peripapillary PFD in Parkinson’s disease (PD). We assess longitudinal rate of change retinal microvascular structural parameters PD vs controls with normal cognition. Method Subjects were imaged using Zeiss Cirrus HD-5000 AngioPlex. Those confounding medical or ocular comorbidities excluded. Superficial capillary plexus (SCP) vessel (VD) assessed within ETDRS 6×6 circle, inner ring, outer ring 3×3 circle ring. SCP foveal avascular zone (FAZ) area was assessed. PFD, VD, FAZ, nerve fiber layer (RNFL), ganglion cell-inner plexiform (GCIPL), central subfield thickness (CST) measured at 2 time points 1 year apart. Rate per calculated. Generalized estimating equations analyzed associations between imaging PD. Result 74 eyes 40 patients (60% male, mean age 67.47.9 years) & 149 78 (28% 70.35.8 included. No demographic differences observed groups except higher proportion females (p = 0.001). had a greater decline (mean 0.021, control 0.00, p 0.001), (PD 0.018, 0.001, .007), 0.022, 0.016, 0.002, p<.001), p<0.001). VD 0.72/mm, 0.054/mm, 0.006), 0.636/mm, 0.048/mm, 0.03), 0.746/mm, 0.005), 0.939/mm, 0.006/mm, p<0.001), -0.942/mm, 0.013/mm, decrease GCIPL 0.403µm, 0.128µm control, 0.01). There no significant FAZ area, RNFL thickness, CST, when stratified by severity. Conclusion may be associated more rapid loss densities thinning compared to aging